How IZERVAY works

IZERVAY is proven to slow GA progression

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How IZERVAY worksClinical resultsSide effects

How IZERVAY works

IZERVAY slows GA progression by directly targeting C5

C5 is a key source of retinal cell death and loss of photoreceptors

Overactive immune system icon

In people with GA, a part of the immune system becomes overactive.

C5 signals icon

A protein called C5 signals other proteins to start attacking retinal cells.

Blocking C5 protein icon

Only IZERVAY blocks the C5 protein to help protect healthy retinal cells and photoreceptors.

The sooner you treat GA, the sooner you may slow its progression

Treat GA early

Clinical results

IZERVAY slowed GA progression in just one year

IZERVAY was proven to slow GA progression in 2 clinical trials evaluating 624 people with GA. IZERVAY slowed GA progression by 18%-35% compared to those who were not treated.

SLOWER PROGRESSION IN JUST 1 YEAR OF TREATMENT

Trial 1

(N=177)

Trial 1: IZERVAY slowed GA progression by 35%

Trial 2

(N=447)

Trial 2: IZERVAY slowed GA progression by 18%

Slowing GA progression may help to preserve vision longer

Side effects

IZERVAY was evaluated in 2 clinical trials

IZERVAY was well tolerated, with less than 2% of people stopping treatment due to side effects

Most common side effects at 12 months:Treated with IZERVAY
(n=292)		Not treated with IZERVAY
(n=332)
Blood in the white of the eye13%9%
Increased eye pressure9%1%
Blurred vision*8%5%
Wet AMD7%4%
Eye pain4%3%
Spots in vision2%<1%
Eyelid inflammation2%<1%

*Blurred vision includes visual impairment and/or loss of sharpness or detail at a distance.

These are not all the possible side effects of IZERVAY. Talk to your doctor if you think you might be experiencing side effects.

Download the complete brochure to learn more about IZERVAY

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Getting started

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAYTM?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

  • Have an infection in or around your eye
  • Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

  • Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
  • Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
  • There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
  • IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

  • Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
  • Have high pressure in the eye or if you have glaucoma.
  • Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
  • Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

  • Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

  • Blood in the white of the eye
  • Increase in eye pressure
  • Blurred vision
  • Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information for more information.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAYTM?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

  • Have an infection in or around your eye
  • Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

  • Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
  • Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
  • There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
  • IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

  • Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
  • Have high pressure in the eye or if you have glaucoma.
  • Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
  • Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

  • Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

  • Blood in the white of the eye
  • Increase in eye pressure
  • Blurred vision
  • Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information for more information.