Introducing IZERVAY

IZERVAY slows GA, which could help preserve your vision longer

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How IZERVAY works Clinical results Side effects

How IZERVAY works

IZERVAY slows GA progression by protecting healthy retinal cells

In people with GA, a part of the immune system becomes overactive.

When this happens, immune system proteins in the eye start attacking healthy retinal cells.

Only IZERVAY blocks an immune system protein called C5 to help protect healthy retinal cells for longer.

Feel confident in managing your GA by partnering with your retina specialist to start treatment today

Treat GA early

Slow GA with IZERVAY

Video_Slow Geographic Atrophy (GA) with IZERVAY

See how IZERVAY works to slow GA progression and what to expect during treatment.

Chapter 3: Slow geographic atrophy—or GA—with IZERVAY (avacincaptad pegol).

Let’s talk about IZERVAY.

IZERVAY is a prescription eye injection that is an FDA-approved treatment proven to slow GA progression.

It’s important to know some safety information about IZERVAY. Do not take IZERVAY if you have an infection or active swelling in or around your eye. Watch this entire video for more Important Safety Information.

So, how does IZERVAY work?

In people with GA, a part of the immune system becomes overactive.

A protein...

...called C5...

...signals other proteins to start attacking retinal cells.

Only IZERVAY...

...blocks the C5 protein to help protect healthy retinal cells and photoreceptors.

IZERVAY is proven to slow GA progression...

...which may help preserve vision longer. IZERVAY is an eye injection...

...given in the office by your doctor.

The idea of an eye injection may sound scary, but it is a common medical procedure.

To prepare, your doctor will clean and numb your eye to help reduce discomfort.

The injection typically takes a few seconds. You may feel pressure in the eye but, usually, little to no pain. Afterwards, you may experience eye redness, blurry vision, or an increase in eye pressure.

It’s important to follow your doctor’s post-treatment care instructions...

...and call them right away if you think you might be experiencing side effects.

Staying on treatment as recommended by your doctor is important to receive the full benefits of IZERVAY.

The earlier you slow GA progression, the longer you may preserve your vision.

Hmm...

So, what’s important to you as you think about your vision?

Hmm...

Don’t delay. Talk to your doctor about...

...slowing GA—with IZERVAY!

Stay tuned for Important Safety Information, and then the main feature—you, teaming up with your doctor.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY™?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

Have an infection in or around your eye
Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
Have high pressure in the eye or if you have glaucoma.
Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

Blood in the white of the eye
Increase in eye pressure
Blurred vision
Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.

Clinical results

Protect healthy retinal cells for longer with IZERVAY

IZERVAY is proven to slow GA progression, which could help preserve your vision for longer

IZERVAY significantly slowed GA progression by 18% to 35%, compared to those who were not treated, in 2 clinical trials evaluating 624 people with GA.

SLOWER PROGRESSION IN JUST 1 YEAR OF TREATMENT

Trial 1

(N=177)

Trial 2

(N=447)

Protection of healthy retinal cells in just 1 year of treatment

I want to preserve my vision for as long as I can, which may help me keep doing the things I love. IZERVAY is helping me do that.”– Mary, real GA patient

Side effects

IZERVAY was evaluated in 2 clinical trials

IZERVAY was well tolerated, with less than 2% of people stopping treatment due to side effects

Most common side effects at 12 months:	Treated with IZERVAY (n=292)	Not treated with IZERVAY (n=332)
Blood in the white of the eye	13%	9%
Increased eye pressure	9%	1%
Blurred vision*	8%	5%
Wet AMD	7%	4%
Eye pain	4%	3%
Spots in vision	2%	<1%
Eyelid inflammation	2%	<1%

*Blurred vision includes visual impairment and/or loss of sharpness or detail at a distance.

These are not all the possible side effects of IZERVAY. Talk to your doctor if you think you might be experiencing side effects.

I've prescribed IZERVAY because of its effectiveness and overall safety profile.”– Dr. Nicholas Anderson

Physicians featured on IZERVAY.com have been compensated.

See what you can expect from IZERVAY treatment

Getting started

IMPORTANT SAFETY INFORMATION AND USE

Do NOT receive IZERVAY^® if you:

Have an infection in or around your eye
Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
Have high pressure in the eye or if you have glaucoma.
Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

Blood in the white of the eye
Increase in eye pressure
Blurred vision
Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information for more information.

What is IZERVAY?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

IMPORTANT SAFETY INFORMATION AND USE

Do NOT receive IZERVAY^® if you:

Have an infection in or around your eye
Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
Have high pressure in the eye or if you have glaucoma.
Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

Blood in the white of the eye
Increase in eye pressure
Blurred vision
Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Please see full Prescribing Information for more information.

What is IZERVAY?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).