Mom and I, we’ve always had a very close relationship, and we love to travel together.

Jan and I click, and we have so much fun together. I—I can’t imagine travelling with anyone else.

I mean she’s my mom, but she’s also my best friend.

And we laugh. Every day she makes me laugh, so… I love her. What can I say?

In my thirties, I had an eye procedure, and they noticed there was something was wrong with my retina. I was referred to my current eye doctor, Dr. Yackey. She performed a series of tests, and when the results came back, she told me that I have macular degeneration.

Later, my eye doctor told me that my macular degeneration had progressed into geographic atrophy, or GA. Why is this happening? Why am I losing my eyesight? It was just really hard.

I was scared to death that I was going to go blind. I was scared that I was going to have to give up work and go on disability.

Macular degeneration is a condition that leads to significant vision loss in the advanced stages. Once atrophy starts to form, we cannot bring back vision. That means that there’s geographic atrophy. When Jan was first diagnosed with geographic atrophy, I explained to her that she would slowly lose her vision.

When Dr. Yackey told us that Jan was losing her eyesight, I asked Dr. Yackey, “Please, could I give her one of my eyes?” My heart breaks for her that she’s going through this when it should be me at my age, not her at her age.

I love to cook, and now, Mom has to help me measure things out so I’m not as independent as I once was. In my forties, my eyesight started to get worse, and it was harder to drive at night. Later, I even noticed my eyesight getting worse in the daylight. That terrified me.

It was scary when she pulled over and said, “Mom, I can’t drive anymore.” She gave up her driver’s license, which I was very proud of her for that.

My eye doctor referred me to a retina specialist, who told me about a treatment for GA called IZERVAY.

Once I referred Jan to the retina specialist for treatment, they talked about her treatment options, and one of the potential options that we have today is to introduce her to IZERVAY.

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection used to treat geographic atrophy, the advanced form of dry age-related macular degeneration.

The goal of the medication is to slow the progression of geographic atrophy. Slowing geographic atrophy progression may help preserve vision longer.

I decided to give IZERVAY a chance because it was hope.

When I went to go receive my first IZERVAY injection, I was nervous. I didn't know what to expect. I didn't know if it was gonna be painful, but it was like a big pinch. It wasn't that bad, and it's helping. That's the main thing.

I want to preserve my vision as long as I can, and IZERVAY is helping me do that. This is just my experience, and your experience might be different.

I plan on travelling with my best friend for as long as we both can. Having this time with my mom is a blessing. Being able to do things together, have fun together…

Laugh together…

Laugh together. It means the world to me.

Yeah, and to me.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY™?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.

I'm a former teacher, so learning has always been very important to me. I love to see the world because I'm curious about other people and other places.

I've seen a lot over the years, but when I got my diagnosis of geographic atrophy, it scared me. I was terrified that I wouldn't be able to appreciate the world around me. I had seen an ophthalmologist for years, but at a certain point the ophthalmologist said that I was having trouble with my retinas.

I knew something was wrong. Luckily for me, my son is a retina specialist.

When my mom first told me what was happening, I wasn't just concerned as a retina specialist, but also as a son. So, I wanted to get her into the office and get her tested as soon as possible.

When I saw those test results, I diagnosed my mother with dry age-related macular degeneration. Macular degeneration is certainly one of the most common things that I see in my practice, but it's definitely different when it's your own mother.

A couple of years later, her dry macular degeneration progressed to geographic atrophy or GA.

GA is an advanced form of dry AMD that can lead to irreversible vision loss.

GA causes cells in your retina to die, also known as atrophy. This causes patches of dead cells, called lesions, that cause vision loss.

She's an avid reader. She's an avid traveler. She spends time with friends and family. And so, I was concerned that the GA could have a significant impact on her life.

It's always a difficult conversation with any patient. When it's my own mother, it was a much more difficult conversation to have.

Well, I had never heard of GA. I didn't have the slightest clue of what it was, but little by little, I began to understand what the issue was.

The thing that people are most afraid of is they're going to go blind or that they're not going to see well at all. So, I would be afraid of losing the ability to read, to take care of myself in general.

Our next step was to look for a treatment that could help slow the progression of my GA.

When I first started my career 20 years ago, we did not have any treatment for GA. However, new treatment options were developed and that has just absolutely revolutionized how we take care of our patients.

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection used to treat geographic atrophy. The goal of IZERVAY is to slow the progression of GA.

I've used IZERVAY for several years for many of my patients and I typically use IZERVAY because of both the safety profile and the efficacy profile and that's why I chose it for my own mother.

The idea of eye injection sounded uncomfortable, but I would say the potential benefits of IZERVAY definitely outweighed any fear that I have. And I decided I want to preserve my eyesight for longer.

Since I'm my son's mother, it wasn't appropriate for him to do the injections for me. So, he set me up with another retina specialist in his practice who agreed to see me.

I discussed the risks and benefits of IZERVAY with my new doctor and we decided to move forward with IZERVAY.

When I went to the office for my first injection, I was sure scared. Then when I got into the room, the assistant did take my hand and held it. And of course, the doctor was very nice, and it went pretty well.

After my first injection, I experienced eye redness. I also had blurry vision and some pressure in my eyes. This is just my experience, and your experience could be different.

When I go get my injection, I'm not going to say it's easy, but I'm getting more accustomed to it, more familiar, more comfortable.

If you've just been diagnosed with GA, you need to find a health care team that treats you like family, whether they're your actual family or not.

My patients often asked me how I would treat my own mother, and it's a very easy question for me to answer. Now I can tell them how my own mother is receiving IZERVAY.

To see my mother on a treatment that is slowing her GA progression, means the world to me.

I want all patients living with GA to find a health care provider that has their best interests in mind, especially since GA progression can be unpredictable.

So, it's very important for patients to work very carefully with their health care provider to monitor their symptoms and monitor their condition, because this condition can progress very rapidly. And it's very important to detect those progressions early and get those changes treated early.

Going through this has made me realize how important seeing the world has been to me.

I look forward to spending time with friends and family, reading, doing a little art project that I enjoy so much, so there's plenty to do.

IZERVAY has allowed me to keep looking forward and I can't wait to see what the future has in store.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY™?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.

The relationship I have with my mom is a great one.

She’s the foundation, the bedrock of our family.

She’s selfless. Extremely sweet. Very personable. But she can also be very feisty.

She was diagnosed with something called macular degeneration.

Prior to my mother’s diagnosis, I only attributed any changes to her getting older. She didn’t notice anything. I didn’t notice anything. She would kind of, look at us in a different angle. She couldn’t actually make out faces in some lights.

I’ve only noticed a change with my vision, with my hobbies, in the past two years. I love to garden and cook and travel, and spend time with my family.

I went for a regular exam with an ophthalmologist in 2014 and was diagnosed with dry macular degeneration. And it developed into geographic atrophy.

After her diagnosis of GA, as a family, we researched how serious it was. It’s devastating to know that your mother is going to go blind, is pretty hard to take.

We came upon IZERVAY as a treatment option.

After doing the research and consulting with my retina specialist, who explained all of the possible risks, I decided to go with IZERVAY as my treatment.

I have been receiving IZERVAY for about a year and a half now, and it has slowed down the progression.

It provided hope. Hope that she’ll be an active grandma and she’ll still maintain her independence.

The advice I would offer to others is not to hesitate.

On a personal level, I started going to an eye doctor, So, I take my mom’s experiences with her eyesight, and I incorporate it into my life with my children and pretty much everybody I talk to too, because, people are unaware.

I feel loved and cared for, and it’s really important to have a supportive family.

This is just my experience, but your experience may be different.

IMPORTANT SAFETY INFORMATION AND USE

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.

What is IZERVAY^TM?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

A part of my personality has always been the creative side. Even now when I'm retired, I stay active in my creative community.

I'm part of the clay club, the fused glass club and line dancing club.

Clay has a memory. And so, you're kind of combining with that clay and creating something together with it. Sometimes, the way clay works is out of your control, and you have to watch it through the process.

Sometimes, your own health can be out of control as well. When I started having eye problems, I knew that I had to find a way to continue to be active.

It all started when I was 60 years old. I went to get a routine eye exam from an optometrist. When I went to the optometrist, she asked me if she could dilate my eyes.

But what she said when she looked into my eyes was that she saw the markers for macular degeneration. And she suggested that I go to an ophthalmologist and have my vision and my eyes checked.

I went to my ophthalmologist and he confirmed it. I was diagnosed with dry age-related macular degeneration, or AMD.

I asked him what I could do, and he said that my eyesight might get worse, but for now, just wait and watch.

I trusted my ophthalmologist. I stayed diligent with my appointments.

Years later, I said to him, “You know, it's the funniest thing, but when I look at the light poles outside, they almost look curved.”

He didn't think that was funny. He said, now it's time to go see a retina specialist.

In my late 60s, my retina specialist told me that my macular degeneration had progressed to geographic atrophy. First in my left eye, then in my right eye.

Back then, there was no treatment for GA, and I just adapted. I kept doing the things I love just differently.

In the clay club, for instance, I had a ruler, my own personal ruler, and I marked it up for myself and so that I could see the markings and I knew what they were.

One of the biggest challenges for me in the clay studio and just in life has been difficulty if somebody is a distance from me recognizing their face. I had someone say to me once, you were staring right at me and you didn't say hello.

Now, I say hello to everybody, whether I know them or not. That's just how I get by.

I did my own research on treatments and I kept up with the news.

That’s how I first heard about IZERVAY (avacincaptad pegol intravitreal solution), a prescription eye injection used to slow the progression of GA.

I was immediately interested. When I read that IZERVAY received FDA approval, I didn't waste time.

I would hear my retina specialist refer to my eyes as stable. At this point, my eyes were not stable.

At my next appointment, I spoke to my doctor. I reiterated that I was eager to start treatment as soon as possible.

I've never stopped advocating for my health, especially since my geographic atrophy diagnosis. I only have one patient to look out for, my doctor has hundreds.

I wanted to do anything I could to preserve my vision for longer. And so, I was excited to start IZERVAY.

A few weeks later, I received a call from my retina specialist’s office. They asked me to come in for my first IZERVAY injection. I was so happy to get that call.

Prior to starting treatment with IZERVAY, we discussed the most common side effects, which include blood in the white of the eye, increase in eye pressure, blurred vision, and wet age-related macular degeneration.

My retina specialist explained to me in detail how IZERVAY may help and how IZERVAY is designed to protect healthy retinal cells and slow the GA progression.

From my experience, my doctor numbs my eye and has me look away. I don't even see the needle. The most I feel is a bit of discomfort.

This is just my experience. Yours may be different.

After my injection, my husband drives me home and I rest my eyes. Sometimes I might feel a little sore the next day. I typically give it a few days before I go back to the dusty environment of clay or go into a pool.

Even when my husband and I travel, I make arrangements to get my scheduled IZERVAY injections at a local retina specialist's office. That way, I never miss an injection.

I’ve been on IZERVAY for a while now, and when I asked my doctor if it was helping, he pulled up my scans and showed me that there had been very little change in the progression of my geographic atrophy since starting IZERVAY.

I've continued living life on my terms, staying active and doing what I love. I'm still dancing, creating and enjoying my time with my friends.

GA has not stopped me. Preserving my sight is incredibly important to me. It's not just about seeing. It's about continuing to live the life I love and doing the things that bring me joy for longer.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY™?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.