Understanding AMD and GA 
AMD happens in 3 stages:
early, intermediate, and advanced.
The advanced form of dry AMD is called GA 

What happens to your eye in GA?

In GA, cells in your retina die, also known as “atrophy.” This creates patches of dead cells in your eye called “lesions” that cause vision loss.

Side view of eye

Retina

Senses light and converts it into signals that your brain turns into images.

Macula

The center of your retina that helps you see details.

Fovea

Responsible for your sharpest and clearest vision.

IZERVAY is a treatment for GA, the advanced form of dry AMD.

Signs and Symptoms
Recognize subtle symptoms to understand if
your GA is progressing
Select a symptom to view its impact.
GA Symptoms
Blurriness or blank spots in the field of vision can be a result of GA
Difficulty seeing in low light or at night is a symptom of GA
Washed-out colors a common sign of GA
Straight lines may look wavy or crooked due to GA
*Image is for illustrative purposes and should not be taken as real medical advice. Talk to your doctor if you are experiencing any or multiple of these symptoms.

GA progression is different for everyone.

Even if your symptoms are subtle or you have no symptoms at all, GA may still be progressing. 

Rapid Progression
Your GA progression may be happening faster than you think

In as few as 2.5 years,* GA can spread to the fovea, where vision is sharpest and clearest.

GA Early Onset

Early Onset

Lesions grow and retina cells die

GA Progression

GA Progression

Lesions grow larger and get closer to the fovea

GA Vision

Severe Vision Loss

When lesions reach the fovea it leads to severe vision loss

*Average time since diagnosis of GA.
GA and you
Vision loss from GA can quickly interfere with your
routine and your independence 
GA Ability To Drive
1.6 YEARS

67% of people with GA lose the ability to drive*

*People with GA in both eyes.
GA 2 Lines Of Vision
2 YEARS

50% of people with GA lose 2 lines of vision

Ask your doctor how your GA is progressing.

Together, you can work on a treatment plan to slow GA progression. 

The goal of treatment is to slow the
progression of GA

See How IZERVAY Works
INDICATION AND IMPORTANT SAFETY INFORMATION

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?
Do NOT receive IZERVAY if you:
  • Have an infection in or around your eye
  • Have active swelling in or around your eye that may include pain and redness
IZERVAY can cause serious side effects:
  • Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
  • Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
  • There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
  • IZERVAY may cause a temporary increase in eye pressure within minutes after the injection. Your healthcare provider will monitor this after each injection.
Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:
  • Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
  • Have high pressure in the eye or if you have glaucoma.
  • Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
  • Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.
What should I avoid while receiving IZERVAY?
  • Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.
What are the most common side effects of IZERVAY?
  • Blood in the white of the eye
  • Increase in eye pressure
  • Blurred vision
  • Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. To request medical information or to report an adverse event or product complaint, please call 1-800-727-7003 or send an email to medinfo.americas@astellas.com.

Please see full Prescribing Information for more information.