Hello, my name is Doctor John Kitchens.

I’m a vitreoretinal surgeon and partner at Retina Associates of Kentucky in Lexington, Kentucky. Today, I’d like to talk to you about dry age-related macular degeneration. It can progress to an advanced form called geographic atrophy, or GA. And GA can lead to irreversible vision loss.

It’s so important to diagnose GA early, so you have the opportunity to start treatment to slow its progression. This is extremely important because many of my patients don’t realize that the clock is ticking. They think they have time, but GA is definitely not a wait-and-see situation.

Geographic atrophy, or GA, is a type of dry macular degeneration. It results when you lose a tissue layer in the back of the eye called the retinal pigment epithelium.

The retinal pigment epithelium supports the retina. It helps the retina function. And when you lose that tissue, unfortunately, over time, the overlying photoreceptors in the retina, they’re lost as well. The result is permanent vision loss.

To diagnose and monitor progression of GA, we use imaging techniques such as optical coherence tomography, fundus autofluorescence, and color fundus photography. All of these tests help us visualize the layers of the retina and the layers under the retina, and identify any lesions or other atrophic changes before GA significantly impacts vision.

Now imagine how this could look if diagnosis and treatment occurred earlier in the disease.

You know, most patients understand immediately what’s happening with their eyes when they see scans like this. It’s almost like a time machine. We can go back in time and say, this is what your retinas looked like two years ago. This is how much atrophy you had two years ago, and here’s where it’s progressed to.

The progression rate for GA can really vary. Some patients may experience rapid changes while others have a slower progression.

I tell my patients it’s impossible to know the speed of progression, so it’s important to treat early. Regular monitoring is crucial to track changes and adjust the treatment plan as needed.

While treatment will not reverse damage, early intervention can slow the progression of GA. So there’s an urgency for slowing progression, which can help preserve remaining vision for longer. This can help the patient continue their routine and independence for longer, potentially to delay their need for adaptive aids such as magnifiers and large-print materials.

IZERVAY works to slow GA progression by directly targeting C5, a key source of retinal cell death and loss of photoreceptors.

The earlier you act to receive treatment with IZERVAY, the longer we may be able to preserve your vision.

I think IZERVAY gives patients the belief that this is a good first step, that it really helps to give them some degree of hope that they’ll have more time with their vision.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY™?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.

Hello. My name is Doctor Esther Kim. I’m a vitreoretinal surgeon at Orange County Retina in Orange County, California.

For patients diagnosed with geographic atrophy, or GA, who are considering treatment, now’s the time to act to slow your GA progression, which may preserve your vision for longer.

I want to help you understand IZERVAY (avacincaptad pegol intravitreal solution) so you can decide whether it’s right for you or your loved one.

Until recently, there were no FDA-approved treatment options for GA. That’s why it’s so remarkable that we’re finally able to do something about GA and empower patients to partner with a retina specialist to take action.

IZERVAY is a safe and effective eye injection that’s proven to slow the progression of GA.

In 2 clinical trials of 624 people, IZERVAY was proven to slow GA progression by 18 to 35 percent in one year, compared to those who were not treated. In regards to safety, IZERVAY was well tolerated in the 2 trials. Less than 2% of people stopped treatment due to side effects.

The most common side effects of IZERVAY are: blood in the white of the eye, increase in eye pressure, blurred vision, and wet age-related macular degeneration.

These are not all the possible side effects of IZERVAY. Talk to your doctor if you think you might be experiencing side effects.

IZERVAY is a trusted treatment option that is already having a positive impact on people with GA and their loved ones.

Over 1,000 eye care offices in the US are experienced with IZERVAY. That means that across the country, patients with GA are able to take action now and start treatment that may preserve their vision longer.

My patients tell me they feel empowered knowing there’s an option like IZERVAY. Many of them are still early in the disease, not yet experiencing serious symptoms. Still, I recommend they start treatment right away, because once vision has been lost due to GA, unfortunately, there’s currently no way of getting that back.

For GA patients, the idea of receiving an eye injection may seem unnerving, but I tell my patients that the anticipation of the first treatment is usually the worst part.

Here’s what you can expect:

IZERVAY is given in the office by your retina specialist. During the office visit, your doctor will thoroughly sterilize and numb your eye, to help reduce discomfort and prevent an eye infection. The injection itself typically takes a few seconds. You may feel pressure in the eye, but usually little to no pain. After the injection, you may experience eye redness, blurry vision, or a temporary increase in eye pressure.

It’s ideal to have someone drive you to and from your appointment, especially for your first injection. It’s important to follow your doctor’s post-treatment instructions, and call them right away if you think you might be experiencing side effects.

Keep in mind that eye injections are very common medical procedures, and retina specialists are very experienced in giving them. For some patients with minimal symptoms from GA, it may be difficult to grasp the importance and urgency of starting treatment. Once your vision is lost, it cannot be restored.

I remind my patients why they initially sought treatment—because changes in their vision were impacting their ability to read or drive, or their grandchildren’s faces were starting to appear blurry.

IZERVAY treatments are a long-term commitment, so it’s important to stay motivated once you start to be sure you get the full treatment benefits.

I trust IZERVAY because it’s a proven and widely accepted treatment to slow the progression of GA.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY™?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.

Hello. I’m Dr. Veeral Sheth, director of clinical trials at University Retina in Chicago, Illinois.

As a retina specialist, it’s important for me to explain to my patients that geographic atrophy, or GA, is a chronic condition that may require chronic treatment.

IZERVAY is proven to slow GA progression, and slowing GA may help preserve your vision for longer.

Let’s explore why starting and staying on IZERVAY may be the right decision for you.

Your condition, GA, is an advanced stage of age-related macular degeneration that’s caused by progressive damage to cells in the retina, resulting in ongoing and permanent vision loss. Everyone experiences GA symptoms differently, and there’s no way of knowing how fast it will, or could, progress. With retinal scans, we can see how fast it’s progressing to that point.

I often say, “Geographic atrophy is like a runaway train.” Once the train gets going, it can be unpredictable and move quickly, causing irreversible damage along its path.

Similarly, GA progression leads to permanent loss of vision that can’t be reversed.

IZERVAY acts like the braking system on that train. It can slow the train down, but it can’t completely stop it.

Using IZERVAY to pump the brakes slows GA progression, which may help preserve your vision longer.

To receive the full benefits of IZERVAY—and keep pumping that brake—you need to stay motivated and continue treatment as recommended by your doctor.

It’s always my advice to keep up the momentum: Stick with your treatments, keep coming in for those appointments, and make your next appointment while you’re still in your provider’s office.

There are several things I found during my practice that keep patients motivated to start or stay on treatment, such as:

• Encouragement from their providers, family members and caregivers
• Having a positive experience in our clinic, and being comfortable with treatments like the injection procedure itself
• And asking my patients, “When it comes to your vision, what’s important to you?”

The biggest motivator is hope—hope that treatment will preserve their vision for longer.

My personal experience with IZERVAY has been positive. The treatment process and flow of patient encounters fit well with how our clinics are designed to give patients the best experience.

My peers, which include referring doctors, like optometrists, are excited about IZERVAY. Until 2023, we didn’t have an FDA-approved treatment for our patients that could slow GA down.

Many of us have been treating people with GA for many years, and it’s great to finally have options for them that can benefit them in the long run.

I trust IZERVAY because across 2 clinical trials, we have evidence that the treatment is effective at slowing down the progression of geographic atrophy.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is IZERVAY™?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection, used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

What is the most important information I should know about IZERVAY?

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com.

Listen, getting older comes with a to-do list – appointments, screenings and being more meticulous about your health.

I’m Babs, social media's favorite grandma and proud spokesperson for IZERVAY.

I’m so happy to spread the news about good eye healthcare and the importance of early detection and taking care of yourself.

I make the most every day.

If you’re gonna take care of yourself, you might as well look good doing it!

I run my errands and still find time to meet with friends and spend time with family. And yes, I think about aging too.

One thing I don’t ignore: my eyes.

I get them checked regularly.

My father had vision loss, and for him it turned out to be dry age-related macular degeneration, and now my sister has it, so it obviously runs in my family.

Dry age-related macular degeneration can progress to an advanced form, geographic atrophy or GA.

I’ve learned that GA causes irreversible vision loss.

If you have GA, the sooner you get diagnosed and can discuss treatment options with your retina specialist, the better.

One treatment option to consider is IZERVAY. IZERVAY won't reverse damage from GA, but it can help slow the progression, which may help preserve existing vision for longer.

Talk to your doctor about important safety information such as not taking IZERVAY if you have an active infection in or around the eye or swelling around the eye that includes pain and redness.

So even if you noticed a slight difference in your vision, you need to have that checked immediately.

GA may still be progressing, and it can move faster than you think. That’s why it’s so important to have annual eye exams, so your eye doctor can spot it early.

It is so reassuring to know that now there are treatments to help slow the progression. If you’re diagnosed with GA talk to your doctor about your options, including IZERVAY.

Of course, I can whip up a family favorite dessert and get my eye exam done on the same day.

Delicious as usual, the Babs way works every time.

IMPORTANT SAFETY INFORMATION AND USE

Do NOT receive IZERVAY if you:

• Have an infection in or around your eye
• Have active swelling in or around your eye that may include pain and redness

IZERVAY can cause serious side effects:

• Eye injections like the one for IZERVAY can cause an eye infection (endophthalmitis) or separation of layers of the retina (retinal detachment).
• Call your healthcare provider right away if you have redness of the eye, eye pain, increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small specks floating in your vision, flashes of light, or increased sensitivity to light.
• There is a risk of developing wet AMD with IZERVAY. You should report any symptoms (visual distortions such as straight lines seeming bent, deterioration in vision, dark spots, loss of central vision) to your healthcare provider to monitor.
• IZERVAY may cause a temporary increase in eye pressure after the injection. Your healthcare provider will monitor this after each injection.

Before receiving IZERVAY tell your healthcare provider about all of your medical conditions including if you:

• Have a history of seeing flashes of light or small specks floating in your vision and if you have a sudden increase of size and number of these specks.
• Have high pressure in the eye or if you have glaucoma.
• Are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
• Are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Tell your healthcare provider about any medicine you take.

What should I avoid while receiving IZERVAY?

• Your vision may be impaired after receiving an eye injection or after an eye exam. Do not drive or use machinery until your vision has recovered sufficiently.

What are the most common side effects of IZERVAY?

• Blood in the white of the eye
• Increase in eye pressure
• Blurred vision
• Wet age-related macular degeneration

These are not all the possible side effects of IZERVAY. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information on IZERVAY.com

What is IZERVAY^TM?

IZERVAY (avacincaptad pegol intravitreal solution) is a prescription eye injection used to treat geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD).

Man, I love this place.

But when my dry AMD progressed to geographic atrophy, or GA, I was worried I’d be seeing less of it.

My retina specialist told me that IZERVAY protects healthy retinal cells longer, and is proven to slow GA,

Slow it down. Get GA goin’ slower.

…which could help me see what I love for longer.

I. ZER. VAY.

Get GA goin’ slower.

IZERVAY is an eye injection.

Don’t take it if you have an infection or active swelling in or around your eye.

IZERVAY can cause eye infection, retinal detachment, or increased risk of wet AMD.

IZERVAY may cause blood in the white of the eye, blurred vision, or a temporary increase in eye pressure.

Do not drive or use machinery until vision has recovered after an eye injection or exam.

With IZERVAY, I’m taking action to slow my GA, and seeing him out there—means everything to me.

Ask your retina specialist how you could help preserve your vision longer with IZERVAY.

Are you living with dry AMD?

If so, you could be on the road to geographic atrophy or GA.

GA can be unpredictable and progress rapidly, causing irreversible vision loss.

But with IZERVAY, you can...

Slow. It. Down.

Get it goin’ slower.

Ask your doctor about IZERVAY.

I. ZER. VAY.

Gets GA goin’ slower.

IZERVAY is the #1 Prescribed FDA-approved treatment for new GA patients.

IZERVAY is an eye injection.

Don’t take it if you have an infection or active swelling in or around your eye.

IZERVAY can cause eye infection, retinal detachment, or increased risk of wet AMD.

IZERVAY may temporarily increase eye pressure.

Do not drive or use machinery until vision has recovered after an eye injection or exam.

IZERVAY is proven to slow GA progression, which may help preserve your vision longer.

I. ZER. VAY.

Gets GA goin’ slower.

Slow your GA.

Don’t delay. Ask your doctor about IZERVAY today.

If you’re living with dry AMD, you may be at risk for developing geographic atrophy, or GA.

GA can be unpredictable—and progress rapidly—leading to irreversible vision loss.

Now there's something you can do to...

Slow. It. Down.

Get it goin’ slower.

Ask your doctor about IZERVAY.

I. ZER. VAY.

Gets GA goin’ slower.

IZERVAY is an eye injection.

Don’t take it if you have an infection or active swelling in or around your eye.

IZERVAY can cause eye infection, retinal detachment, or increased risk of wet AMD.

IZERVAY may temporarily increase eye pressure.

Do not drive or use machinery until vision has recovered after an eye injection or exam.

IZERVAY is proven to slow GA progression which may help preserve vision longer.

I. ZER. VAY.

Gets GA goin’ slower.

So shift gears and get going.

Don’t delay. Ask your doctor about IZERVAY.